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RatInhalRNA focuses on developing effective RNA delivery systems for lung therapy. By using computational methods and machine learning, the project aims to create inhalable formulations that enhance the delivery of small interfering RNA to treat diseases affecting the lungs.
The overarching goal of RatInhalRNA is to computationally predict and develop efficient formulations for pulmonary RNA therapy.
New RNA formulations are imperative for clinical RNA delivery beyond the liver.
The lung offers undruggable targets which could be treated with RNA therapeutics.
However, approved siRNA formulations are not suited for pulmonary delivery due to instability in lung surfactant and during nebulization.
Hence, it is my aim to rationally design inhalable and biocompatible pol…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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