CORDIS Project
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This project investigates the role of the nucleolar genome in DNA damage and genomic instability related to aging and cancer. By utilizing advanced techniques like gene editing and live cell imaging, it aims to identify factors that protect nucleolar integrity under various stress conditions.
Incidence of grave pathologies including neurodegeneration and cancer increases in today’s aging European populations and new approaches to battle these diseases are required.
Shared by these pathologies and premature aging syndromes is the enhanced DNA damage and genomic instability, likely causal phenomena that can be better understood by functional elucidation of the cellular DNA damage response (DDR) machinery and its defects.
The central hypothesis of this project is that ‘nucleolar genome’…
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