CORDIS Project
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This project aims to advance synthetic genomics by developing methods for large-scale genome assembly in mammalian cells. It focuses on using CRISPR technology to replace genes associated with Duchenne Muscular Dystrophy.
The assembly of functional synthetic mammalian genomes is the most ambitious biotechnological challenge of the current century.
Synthetic genomics has generated remarkable results in viruses and bacteria, but the de novo assembly of eukaryotic genomes is still limited to a few small chromosomes.
Indeed, efficient delivery and genome engineering strategies for systematic genome replacement and assembly in higher eukaryotic cells are still missing.
With my project RE-GENESis, I intend to make an e…
UNITED KINGDOM RESEARCH AND INNOVATION
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