CORDIS Project
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This project focuses on understanding antigenic variation in the malaria parasite Plasmodium falciparum using CRISPR-Cas9 genome editing. By manipulating gene regulatory elements, the research aims to uncover the molecular mechanisms behind the parasite's immune evasion strategies.
Malaria is an infectious human disease caused by parasitic protozoans of the Plasmodium type. P. falciparum causes the most lethal form with about 400.000 deaths annually.
Pathogenesis involves expression of clonally variant molecules encoded by multi gene families at the surface of the infected host cells (erythrocyte).
The most important virulence factor is called PfEMP1, which undergoes antigenic variation and is encoded by 60 var gene members.
Despite the major scientific efforts, the molecu…
INSTITUT PASTEUR
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