CORDIS Project
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This project investigates the role of the Aryl Hydrocarbon Receptor in the tumor microenvironment and its influence on immune responses against tumors. By identifying specific metabolites that activate this receptor, the project aims to develop strategies to enhance anti-tumor immunity and address therapy resistance.
Owing to an increased appreciation of the potential for immunotherapy in neoplasia, much attention has been focuing on a greater understanding of the immune, bidirectional intricacies involving the Tumor MicroEnvironment (TME).
Recent work has demonstrated that TME elicits environmental changes, metabolic in nature, in the host’s immune cells, that dampen their ability to REACT against tumors.
Manipulating the biology of oncometabolites can strengthen an antitumor immune response as well as circ…
UNIVERSITA DEGLI STUDI DI PERUGIA
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