CORDIS Project
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This project investigates the role of the AAA+ ATPase complex of VCP in disaggregating Tau fibrils, which are linked to Alzheimer’s disease and related dementias. Using advanced imaging techniques, the research aims to uncover cellular mechanisms involved in Tau pathology, potentially leading to new therapeutic strateg…
Age-dependent neurodegenerative diseases associated with protein aggregation represent one of the most important medical and socio-economic challenges of our time.
With the extension of human life span, the prevalence of this group of diseases has markedly increased.
Among them, Alzheimer’s diseases (AD) and other dementias have become the second leading cause of death in high-income countries.
As a pathological hallmark, Tau amyloid aggregation in the brain has been determined to be closely rel…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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