CORDIS Project
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This project focuses on understanding protein quality control through molecular chaperones, which assist in protein folding. Using advanced NMR spectroscopy, it aims to reveal the mechanisms of chaperone action and its implications for diseases like Alzheimer's.
Protein Quality Control is an essential and evolutionary-conserved process that is present in all kingdoms of life.
In cells, both newly synthesized and pre-existing proteins are constantly prone to misfolding and aggregation.
The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging, pathological states and cell death.
Accordingly, cells have developed an enzymatic machinery – molecular chaperones – that rescues misfolded proteins by catalyzing their conversion bac…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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