CORDIS Project
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This project investigates the role of the BRCA1 tumor suppressor gene in breast cancer and its implications for other cancers. It focuses on understanding the genetic and molecular mechanisms that lead to tumor development, aiming to improve targeted therapies for BRCA1-related cancers.
Mutations of BRCA1 tumor suppressor gene account for 5-10% of hereditary breast cancers.
Clinically, BRCA1-mutated cancers represent a unique subtype, with distinctive risk factors and poor prognosis.
High-throughput technologies have identified genomic and transcriptomic signatures that are shared by sporadic and BRCA1-mutated breast tumors. BRCA1 mutations have been implicated in other types of tumors such as gastric, pancreatic and prostate cancers. A more detailed picture of BRCA1 tumor supp…
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