CORDIS Project
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This project aims to enhance imaging techniques to visualize and quantify cell surface proteins at single-protein resolution. By advancing DNA-PAINT microscopy, it seeks to map the nanoscale organization of immunomodulatory proteins on immune and tumor cells, providing insights that could refine immunotherapy strategie…
Targeting cell surface proteins to alter cellular behavior is a major aim of many therapeutics.
Recently approved immunotherapeutic drugs trigger anti-tumor immunity by disrupting key cell surface proteins that guide immune cell interactions.
Despite the cell surface representing a major site of drug action, its nanoscale organization remains poorly characterized.
The main reason for this is largely due to technical limitations of current fluorescence and super-resolution imaging approaches, whi…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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