CORDIS Project
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This project investigates the role of the human ubiquitin-like conjugation system in autophagy, focusing on the function of Atg8 homologs and Atg16 variants. By using in vitro systems and advanced microscopy techniques, the research aims to uncover mechanisms that could inform our understanding of diseases like cancer…
Autophagy is a catabolic pathway that delivers cytoplasmic material to lysosomes for degradation.
Under vegetative conditions, the pathway serves as quality control system, specifically targeting damaged or superfluous organelles and protein-aggregates.
Cytotoxic stresses and starvation, however, induces the formation of larger autophagosomes that capture cargo unselectively.
Autophagosomes are being generated from a cup-shaped precursor membrane, the isolation membrane, which expands to engulf…
INSTITUT PASTEUR
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