CORDIS Project
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This research investigates the molecular mechanisms of focal adhesion formation, focusing on the interactions between key proteins and the actin cytoskeleton. By employing advanced imaging techniques, the project aims to uncover insights into protein assembly and signaling pathways relevant to cell behavior.
Focal adhesions (FAs) are receptor complexes that couple the extracellular matrix (ECM) to the actin cytoskeleton, allowing inside-out and outside-in signaling between cells and their environment.
FA formation is triggered by activation of integrin receptors, which interact with cytoplasmic ligands to connect with the actin cytoskeleton and regulate numerous signaling pathways.
FA maturation requires force transduction between the actin cytoskeleton and ECM, which results in protein recruitment,…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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