CORDIS Project
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This project investigates the developmental lineage of the marine invertebrate Platynereis dumerilii by analyzing gene expression and chromatin accessibility across various stages. It aims to understand how different cell types emerge and are regulated during development, utilizing advanced techniques like single-cell…
Cells in multicellular organisms show a huge diversity of shape, size, and function, yet are all descended from the same totipotent zygote.
As development progresses, cells lose their ability to contribute to different fates, instead committing to a narrower subset of expression programs.
This stepwise reduction of differentiation potential has been illustrated in Waddington’s epigenetic landscape (“Waddington lineage”).
The specific gene expression programs of cell types are governed by Core Re…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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