CORDIS Project
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This project investigates how double strand DNA breaks in E. coli are repaired through homologous recombination. Using advanced genetic screening techniques, it aims to identify the genes involved in this repair process and understand the dynamics of chromosome behavior during repair.
The integrity of genetic information is central to life, yet the DNA is vulnerable to damage from internal and external sources.
Incorrect repair of DNA damage drives mutagenesis, loss of genetic information, ageing, and cancer.
Double strand DNA breaks (DSBs) are perhaps the most threatening DNA lesions, where the integrity of both strands of the DNA duplex is interrupted at the same position.
In E. coli, faithful repair of DSBs is possible only through the homologous recombination (HR) pathway…
UPPSALA UNIVERSITET
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