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The RECYPION project investigates carboxyl polyether ionophores, aiming to explore their antimicrobial properties and develop new synthetic methods. It seeks to understand their cellular activities and potential as alternatives in a post-antibiotic world.
The carboxyl polyether ionophores (CPIs) is a class of >150 complex natural products.
Belonging to the most complicated of Nature's secondary metabolites, they are darlings within total chemical synthesis, however, the biological role of these agents is obscure.
Due to their canonical function of equilibrating ion-gradients across biological membranes, CPIs are thought to be unspecific and largely uninteresting.
Here, I will advocate and demonstrate the opposite position: that not only are these…
AARHUS UNIVERSITET
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