CORDIS Project
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This project investigates the role of mRNA editing in bacteria, specifically how it allows for the production of protein isoforms that may enhance bacterial adaptability to various environments. By exploring this genetic mechanism, the project aims to uncover its prevalence and regulatory factors across different bacte…
Bacteria are haploid, having a single copy of each gene.
We suggest a paradigm shift in bacterial genetics: bacteria can have two RNA versions of the same gene, encoding protein isoforms at the single-bacterium and population level.
These protein isoforms can have altered activity, which could be advantageous under different conditions.Adenosine-to-inosine (A-to-I) mRNA editing can affect the sequence and the function of translated proteins because the ribosome identifies inosine as guanosine. W…
BEN-GURION UNIVERSITY OF THE NEGEV
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