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The REDIRECT project investigates how abnormal sensory information processing in preadolescents, particularly in males, can lead to mental disorders. By using a rodent model, it explores the role of dopamine circuits and sex differences in susceptibility to sensory deficits, aiming to inform targeted therapies for vari…
Mental disorders are associated with abnormal sensory information processing (SIP) at preadolescence, especially in males.
Aberrant SIP is a neutral cross-disorder trait that can be translated between humans and animals and assessed as the inability to prevent/gate an overload of irrelevant information.
The mechanisms underlying physiological and pathological SIP variability are unexplored.
Particularly, the causative role of hyperdopaminergia, key to SIP deficits, has never been tested by isola…
UNIVERSITA DEGLI STUDI DI CAGLIARI
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