CORDIS Project
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This project investigates how alleviating mechanical stress in tumors can improve the delivery and effectiveness of chemotherapy. By using advanced modeling and animal studies, it aims to identify drugs that can normalize the tumor microenvironment and enhance treatment outcomes for various cancers.
Current chemotherapeutic agents are potent enough to kill cancer cells.
Nonetheless, failure of chemotherapies for many cancers (e.g. breast and pancreatic cancers and various sarcomas) is primarily because these agents cannot reach cancer cells in amounts sufficient to cause complete cure.
The abnormal microenvironment of these tumors drastically reduces perfusion and results in insufficient delivery of therapeutic agents.
Tumor structural abnormalities is in large part an effect of mechanical…
UNIVERSITY OF CYPRUS
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