CORDIS Project
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This project focuses on the mechanisms of cell migration, particularly the role of actin dynamics and feedback loops in controlling cell movement. It aims to identify proteins interacting with the WAVE complex and their functions in various cellular models.
Cell migration is a critical process for embryogenesis, immune cell function and wound healing as well as cancer progression.
Most normal cells migrate by protruding the plasma membrane forward through actin polymerization.
The formation of a protrusion requires activation of the small GTPase Rac1 that in turn activates the WAVE complex, which induces branched actin networks through the Arp2/3 complex.
For efficient cell migration, membrane protrusion at the leading edge must be sustained.
Conve…
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