CORDIS Project
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The REGAIN project focuses on developing a local treatment for sensorineural hearing loss by repurposing gamma-secretase inhibitors to regenerate inner ear hair cells. This innovative approach aims to provide a new therapeutic option for millions suffering from hearing loss.
Hearing loss is a chronic non-communicable disease disabling over 328 million adults, and 32 million children worldwide.
Sensorineural hearing loss due to loss of auditory hair cells was long thought to be irreversible.
However, recent animal studies have demonstrated that pharmacological inhibition of cell signalling via Notch receptors using gamma-secretase inhibitors (GSIs) can regenerate hair cells and partially restore hearing capacity.
This novel therapeutic concept provides the first prom…
AUDION THERAPEUTICS BV
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Germany, Tuebingen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Greece, Athina
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United Kingdom, Basingstoke
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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