CORDIS Project
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This project investigates the role of the SWI/SNF chromatin-remodeling complex in prostate cancer, particularly its influence on resistance to anti-androgen therapies. By analyzing chromatin accessibility and androgen receptor binding, the project aims to identify new therapeutic strategies for treating castration-resi…
The significance of epigenetic deregulation is a very hot topic in current prostate cancer (PC) research.
New mutations have been identified in several epigenetic regulators known for their interaction with the AR.
In fact, the role of chromatin remodeling factors facilitating enhancer-promoter cooperation in the formation of the AR transcriptional complex has long been demonstrated.
Accordingly, the marked redistribution of AR binding sites (cistrome) during tumorigenesis is arguably the most r…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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