CORDIS Project
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This project investigates cranial neural crest cells (CNCC) to understand how they can revert to a pluripotent state during development. By analyzing gene regulatory networks and chromatin changes, the research aims to reveal mechanisms of cellular identity reprogramming, with potential applications in craniofacial tis…
Cell differentiation progresses via a continuous lineage restriction process where cell potential is reduced as the embryo develops.
Pluripotent embryonic cells can beget all somatic cell types, but this capacity is rapidly restricted during the formation of the three germ layers, each giving rise to distinct cell types.
Uniquely among vertebrates, a stem cell-like population arising in the embryo rostral part ? called cranial neural crest cells (CNCC) ? challenges this paradigm. CNCC not only g…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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