CORDIS Project
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This project investigates methods to improve nerve regeneration in the spinal cord after injury. It focuses on enhancing the growth of axons through targeted neurotrophic factors and cellular grafts, aiming to restore functional connectivity and promote recovery in affected areas.
Recent studies have indicated that combinatorial treatments that target multiple mechanisms are necessary to address the limited regenerative capacity in the adult nervous system.
We have shown that chemotropic guidance by growth factor gradients, activation of cell-intrinsic regenerative programs and suitable cellular bridges at a lesion site allow for axons to extend across a lesion site in the injured spinal cord.
Further, regenerated axons form ultrastructurally identified synapses with app…
UNIVERSITATSKLINIKUM HEIDELBERG
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