CORDIS Project
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This project investigates the cellular processes involved in muscle fiber growth and repair, focusing on the fusion of muscle stem cells with existing fibers. By utilizing advanced imaging and molecular techniques, it aims to uncover the mechanisms of muscle regeneration and the role of myofibers in this process.
Skeletal muscle fibers are highly organized multinucleated cells that grow and regenerate by fusing with myocytes derived from their resident stem cells.
The fusion between myocytes and mature muscle fibers, which underpins the remarkable adaptability of muscles, is molecularly distinct from the fusion events that occur during development.
This secondary fusion process, also known as myonuclear accretion, integrates mononucleated myocytes into immature myotubes or mature fibers, supporting muscl…
WEIZMANN INSTITUTE OF SCIENCE
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