CORDIS Project
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This project investigates the role of alternative splicing in cell division, aiming to uncover new regulatory mechanisms involved in this fundamental process. It employs advanced sequencing and microscopy techniques to analyze splicing events during mitosis and their implications for diseases like cancer.
The complexity of the mammalian proteome is far more extensive than can be explained by a simple one gene: one protein paradigm.
The use of alternative splicing (AS) is emerging as a core regulatory mechanism, in a similar way to whether a specific gene is transcribed or repressed, or a protein is degraded or stabilised.
Also like both transcriptional and post-translational control, it seems that almost every gene in the human genome undergoes AS.
Despite this, the role of AS in a fundamental ce…
MEDICAL RESEARCH COUNCIL
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