CORDIS Project
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This project investigates the interaction between the dopamine transporter and the PDZ domain protein PICK1, aiming to understand how this relationship affects dopamine signaling. By exploring these molecular interactions, the research seeks to uncover mechanisms that could lead to new treatments for disorders linked t…
The dopamine transporter (DAT) belongs to the family of Na+/Cl- dependent neurotransmitter transporters and is responsible for rapid termination of dopaminergic signaling by mediating reuptake of dopamine (DA) from the synaptic cleft.
The DAT is target for widely abused psychostimulants, such as amphetamine and cocaine, as well as modification in DAT activity has been associated with severe brain disorders like Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder (ADHD…
KOBENHAVNS UNIVERSITET
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