CORDIS Project
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This project investigates the roles of newly discovered RNA polymerases in gene regulation. It focuses on understanding how these enzymes influence RNA processing and translation, particularly in neuronal and reproductive cells, to reveal their biological significance.
In eukaryotes, almost all RNA molecules are processed at their 3’ ends and most mRNAs are polyadenylated in the nucleus by canonical poly(A) polymerases (PAPs).
Recently, several new non-canonical poly(A) (ncPAPs) and poly(U) polymerases (PUPs) have been discovered that have more specific regulatory roles.
In contrast to canonical ones, their functions are more diverse; some induce RNA decay while others, especially cytoplasmic ncPAPs, activate translationally dormant deadenylated mRNAs.
Knowled…
INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK
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