CORDIS Project
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This project investigates the role of iron in neurodegenerative diseases, focusing on the ferroxidase activity of amyloid precursor protein in neuronal iron regulation. It aims to understand how disruptions in iron homeostasis contribute to diseases like Alzheimer's and Parkinson's.
The life essential element iron is required as a cofactor in central nervous system metabolic processes, but unbound iron catalyzes the production of toxic reactive oxygen species.
Neuronal iron accumulation is a common pathological feature in the cortex in Alzheimer’s disease (AD), the substantia nigra (SN) in Parkinson’s disease (PD), and the tauopathies.
Since too much or too little iron can compromise cell viability, cellular iron homeostasis is tightly regulated.
Ferroxidases, oxidize Fe2+…
UNIVERSITY OF LEEDS
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