CORDIS Project
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This project investigates how the gut immune system tolerates commensal bacteria without inflammation. It focuses on the role of lipids derived from these bacteria in modulating immune cell functions, particularly unconventional T cells, to enhance understanding of intestinal immunity and improve treatments for inflamm…
The gastrointestinal tract is continuously exposed to multiple antigens from commensal bacteria, food and pathogens.
The mechanisms by which the gut mucosa tolerates trillions of commensal bacteria without developing inflammation remains poorly understood.
It is increasingly appreciated that commensal bacteria-derived products regulate the homeostasis and/or function of many immune cell populations.
Commensal bacteria-derived lipids are recognized by a population of unconventional T cells, calle…
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