CORDIS Project
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This project investigates how microtubule dynamics and their associated proteins influence the development of mammary gland structures in a three-dimensional culture. By focusing on the interactions between microtubules and key structural components, it aims to enhance understanding of breast tissue architecture and it…
The mammary gland functional unit develops as a result of a complex morphogenetic process organizing polarized epithelial cells into a branched network of ducts terminating in acini.
Most of human breast cancers originate from transformation of epithelial cells and induce breakdown of this structure.
Studies in cells grown in two-dimensional (2D) cultures have shown that microtubules target and regulate actin network and adhesion complexes, which are also known to be essential components of thre…
UNIVERSITEIT UTRECHT
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