CORDIS Project
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This project investigates how mechanical forces influence cell signaling through focal adhesion kinase (FAK) activity. By using light-activated ligands, it aims to control cell adhesion and study its effects on fibrosis in various contexts, enhancing our understanding of cell biology and potential therapies.
Mechanical forces drive fundamental physiological functions in living organisms, yet it remains unclear how forces are transduced into intracellular biochemical signals.
Mechanotransduction is a tightly regulated process, and its disruption often results in pathologies including tumorigenesis, chronic inflammation and fibrotic conditions.
Crucially, recent studies have shown an important relationship between abnormal fibrosis and altered patterns of focal adhesion kinase (FAK) activity and cell…
LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH
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United States, Atlanta
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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