CORDIS Project
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This project investigates the role of Id proteins in regulating the expression of short non-coding RNAs, such as tRNA, in rapidly proliferating cells. It aims to understand how these proteins contribute to cancer development by promoting cell proliferation and inhibiting differentiation.
The Id (Inhibitor of differentiation) family consists of four related transcription factors that are expressed at high levels in rapidly proliferating cells, including those found tumour cells.
Overexpression of Id proteins in transgenic mice causes cancers.
Ids have been shown to inhibit differentiation and promote cell proliferation in a variety of systems.
This is achieved through interactions with other transcription factors such as MyoD, E47 and Ets.
To date, all of the published targets of…
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BEATSON INSTITUTE FOR CANCER RESEARCH LBG
United Kingdom, Bearsden
Type: Research institute
Activity type: Research Organisations
SME: No
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