CORDIS Project
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This project investigates the NF-kB pathway, focusing on the transcriptional activation of specific target genes linked to cancer. By utilizing CRISPR/Cas9 and mass spectrometry, it aims to identify and characterize the factors involved in NF-kB responsive gene regulation, with applications in cancer research and poten…
NF-kB is a family of transcription factors that regulate expression of genes that are involved in various cellular processes such as apoptosis, proliferation and differentiation.
The NF-kB pathway is implicated in the initiation and progression of cancer and cancer cell drug resistance.
Unfortunately, global NF-kB inhibition is harmful to the immune system; therefore, inhibition of a subset of NF-kB target genes that are linked to malignant transformation would be more appropriate.
Different NF-…
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