CORDIS Project
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This project aims to decode the regulatory information encoded in the genome by studying gene regulation in Drosophila. It focuses on understanding how specific transcription factors influence gene expression across different tissues and developing a computational model to predict enhancer functions in various cell typ…
A major goal of biology is to explain how gene regulatory information is encoded by the genome.
To date, we cannot decipher this regulatory code, despite the cells ability to read it in natural and artificial sequence contexts, and in contrast to our detailed understanding of the genetic code, which allows us to seamlessly translate DNA into protein sequences.
Here, I propose a regulatory genomics approach in Drosophila with three specific objectives:
First, we will determine the sequence basis…
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