CORDIS Project
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The project investigates how the composition and stiffness of the basement membrane influence the behavior of intestinal epithelial cells, focusing on their proliferation, differentiation, and migration. By utilizing tissue cultures and mouse models, it aims to uncover the mechanisms that maintain gut health and homeos…
The intestinal epithelium forms a tight barrier against pathogens and toxins while simultaneously absorbing ions and nutrients.
It is the fastest self-renewing tissue in the body, as over 3-5 days, a complete turnover of epithelial cells is achieved.
Homeostasis is maintained by tight coordination between epithelial cell proliferation, differentiation, migration, and extrusion.
Epithelial cells adhere and migrate on the basement membrane, a unique, sheet-like extracellular matrix that separates…
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