CORDIS Project
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ReinforceBG explores the role of dopamine and the basal ganglia in Parkinson's disease, proposing that dopamine loss leads to negative reinforcement of neural dynamics. The project aims to develop a brain-computer interface to modulate these dynamics, enhancing movement and cognitive functions in patients through innov…
Dopamine and the basal ganglia have been conserved over more than 500 million years of evolution.
They are fundamental to animal and human behaviour.
Parkinsons disease (PD) is associated with loss of dopaminergic innervation to the basal ganglia.
Over 6 million people suffer from the debilitating symptoms of PD that span disturbance of emotion, cognition and movement.
There is a pressing need to understand the pathogenesis of these symptoms, but an integrated account of dopamine and basal gangl…
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