CORDIS Project
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This project aims to develop human induced pluripotent stem cells (hIPSCs) as a source of hepatocytes for treating inherited metabolic diseases of the liver. It focuses on improving hIPSC generation, differentiation into liver cells, and correcting genetic defects to provide a safer alternative to liver transplantation…
Liver diseases are becoming one of the most common causes of mortality in developing countries, and orthotopic liver transplantation is the only available treatment.
However, this procedure carries implies indefinite immunosupression treatment associated with heavy side effects and eventual rejection.
Furthermore, an increasing number of patients die while on the liver transplant waiting list due to the shortage of donor livers.
Hepatocyte transplantation recently became an alternative to transp…
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