CORDIS Project
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This project investigates the role of posttranslational modifications, specifically ubiquitin and ubiquitin-like proteins, in regulating T cell function and immune responses. By developing new methods to analyze these modifications, the project aims to enhance understanding of lymphocyte biology and inform future thera…
T lymphocytes are key cells of the adaptive immune system that protect us against pathogens and malignant cells. T cell activation and differentiation are tightly controlled processes and deregulation can result in lymphomas, autoimmunity and inflammation.
Hence, the biochemical events regulating lymphocyte biology have long been a topic of intense research, which has been focussed predominantly on protein phosphorylation. I hypothesize that there are crucial roles undiscovered in T cells for ot…
UNIVERSITY OF DUNDEE
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