CORDIS Project
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This project investigates how microglia, immune cells in the brain, contribute to synapse loss associated with cognitive decline in neurodegenerative diseases. By utilizing advanced genetic and imaging techniques, it aims to identify molecular mechanisms and develop targeted therapies to mitigate synapse loss.
Synapse loss is the major correlate of cognitive impairment in many neurodegenerative diseases.
Recent literature suggests that microglia, which mediate synaptic pruning during brain development, can be responsible for synapse loss in neurodegeneration.
Although the underlying mechanisms are poorly understood, growing evidence indicates that dysfunctional microglia affect synapses number and function in pathology.
Genome-wide association studies reveal that the majority of risk genes associated…
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