CORDIS Project
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This project investigates the mitochondrial pathway of programmed cell death, focusing on the kinetics of mitochondrial outer membrane permeabilization. It aims to understand how variations in this process affect cell survival and apoptosis, with implications for cancer treatment.
The mitochondrial pathway of apoptosis is the major form of programmed cell death in vertebrates.
In this pathway, pro-apoptotic members of the Bcl-2 protein family cause mitochondrial outer membrane permeabilisation (MOMP) leading to the release of mitochondrial intermembrane space proteins that activate caspase proteases and apoptosis.
Regulation of MOMP has been intensively investigated because it represents a crucial, and potentially targetable, process that determines cell survival.Upon ini…
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