CORDIS Project
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The project explores the genetic factors influencing protein reabsorption in kidney cells, particularly focusing on the CUBN gene. By understanding these mechanisms, it aims to develop new strategies for protecting kidney function in diseases characterized by protein leakage.
Many forms of chronic kidney disease are featured by the loss of protein into the urine (proteinuria).
When the cause of proteinuria lies within the glomerulus, such as in diabetic kidney disease, then the protein overload in the tubular lumen may lead to damage of the downstream tubular cells.
Particularly vulnerable are proximal tubular cells (PTCs), because these cells are specialized in protein reabsorption and have a high metabolic demand.
Dysfunction of the main albumin uptake receptor cub…
UNIVERSITATSKLINIKUM HEIDELBERG
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