CORDIS Project
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This project investigates the structure of gamma-secretase, a protein complex involved in Alzheimer’s disease, using advanced imaging techniques like cryo-Electron Microscopy and X-ray crystallography. The goal is to understand how this complex functions and its role in cellular signaling, which could inform future the…
Alzheimer disease (AD) is characterised by the accumulation of beta amyloid peptide cut from a transmembrane precursor.
A large intramembrane complex carries out the proteolysis: gamma-secretase, containing the protease presenilin and other three proteins (nicastrin, aph1, pen2).
G-secretase is involved also in the proteolysis mediated signaling cascade by the transmembrane receptors Notch1 and Erb4, regulating cell growth and differentiation The aim of the project is to gain structural insight…
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
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