CORDIS Project
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This project explores a novel therapy for diabetes by reprogramming pancreatic α-cells to produce insulin. The approach utilizes FDA-approved compounds to induce this transformation, aiming to provide a safe and effective treatment for diabetes.
Diabetes affects some 500 million people worldwide (estimated 700 million by 2045), causing over one million deaths annually.
The disease results from the loss / dysfunction of pancreatic islet insulin-producing β-cells, leading to chronic hyperglycemia and severe complications.
Current treatments are symptomatic and fail to restore long-term glucose regulation, stressing the need for a transformative curative approach.Our proposal leverages α-cell reprogramming as a novel therapy for the restor…
UNIVERSITE DE GENEVE
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