CORDIS Project
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This project investigates the impact of genetic variations, specifically CAG repeat expansions, on brain structure and function in individuals with Huntington disease and healthy controls. By linking these genetic factors to mental health and cognition, the project aims to enhance understanding of neuropsychiatric diso…
Neuropsychiatric disorders such as dementia and depression are among the leading causes of disability and exert a dramatic burden on Europe’s healthcare systems.
In order to devise more effective therapies it is essential to elucidate their genetic basis.
However, to date genetic association studies have only identified a small fraction of the genetic determinants, possibly due to neglect of some important genomic variations, especially DNA repeat expansions.
Expanded DNA repeats above a certain…
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