CORDIS Project
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This project investigates the unique cell cycle characteristics of embryonic and germ stem cells to enhance the reprogramming of somatic cells. By optimizing cell cycle isolation techniques, it aims to understand the role of specific cell cycle phases in maintaining pluripotency and improving cell reprogramming efficie…
Pluripotent embryonic stem (ES) and germ (EG) cells differ from other stem cells in several respects.
They display a characteristically ‘compressed’ cell cycle in which G1 is shortened, contain a high proportion of cells in DNA synthesis (S)-phase and lack several cell cycle checkpoints.
This unusual cell cycle signature is important for maintaining their identity since cell cycle arrest, or lengthening, results in irreversible differentiation, and somatic cells assume this unusual signature whe…
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