CORDIS Project
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This project investigates self-replicating molecules using dynamic combinatorial chemistry to create libraries of macrocyclic molecules. By manipulating peptide sequences and ring sizes, the research aims to understand molecular replication mechanisms and the competitive dynamics of replicators in an open system.
Self-replicating molecules have most likely played an important role in the origin of life.
This proposal explores the use of dynamic combinatorial chemistry for identifying new self-replicating molecules.
We will make dynamic combinatorial libraries of macrocyclic molecules of different ring sizes that can exchange building blocks through reversible covalent chemistry.
The building blocks are equipped with peptides that are predisposed to form beta-sheets.
The building blocks, which carry only…
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