CORDIS Project
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This project investigates the mechanisms of DNA replication, focusing on how cellular machinery maintains efficiency during obstacles. By using advanced imaging techniques, it aims to understand the dynamics of replisome collisions and their implications for genetic stability.
Faithful duplication and transmission of genetic and epigenetic information is the most vital cellularfunction for the preservation and proliferation of life.
In cells, this process is conducted by largemacromolecular complexes, known as replisomes, that coordinate the sequence of enzymatic eventsduring chromosome duplication.
While recently developed single-molecule techniques promiseunprecedented access to the complex inner workings of these sophisticated machines, most studiesconducted have f…
TECHNISCHE UNIVERSITAET MUENCHEN
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