CORDIS Project
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This study investigates the role of ATR kinase in regulating gene expression and replication timing in response to replication stress. It aims to uncover how disruptions in ATR signaling can lead to genomic instability and cancer.
Replication stress has emerged as a prominent driver of genomic instability.
The ATR kinase is a master regulator of the cellular response to replication stress and defects in ATR activation or loss of its signaling components leads to DNA damage, genomic instability and tumorigenesis.
Yet the direct mechanisms by which ATR signaling prevents these repercussions remain poorly understood.
The primary aim of this study is to investigate a novel role for ATR in regulating the cellular replication t…
KOBENHAVNS UNIVERSITET
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