CORDIS Project
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This project investigates the molecular mechanisms governing mitochondrial DNA replication in human cells, focusing on how mutations in replication machinery contribute to neurodegeneration and muscle diseases. It aims to understand the role of mitochondrial DNA in aging and its implications for common age-related dise…
SUMMARYMitochondria are required to convert food into usable energy forms and every cell contains thousands of them.
Unlike most other cellular compartments, mitochondria have their own genomes (mtDNA) that encode for 13 of the about 90 proteins present in the respiratory chain.
All proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA-encoded genes, are encoded in the nucleus.
Mutations in nuclear-encoded proteins required for mtDNA maintenance is an import…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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