CORDIS Project
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This project focuses on reprogramming human glial cells into neurons within a tissue-like environment. By employing advanced genome-editing techniques, it aims to explore the plasticity of cell identity and develop new strategies for brain repair.
Work over the last decade has shown that the genetic programs underlying cell identity are still plastic in terminally differentiated cells.
Direct lineage reprogramming takes advantage of this plasticity to induce cell fate conversions from one cell type into another.
This is achieved by forced expression of specific fate determinants, usually transcription factors that regulate cell fate during development.
This proposal will allow me to address the fundamental biological question whether huma…
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
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