CORDIS Project
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This project investigates the role of chromatin architecture in controlling the timing of DNA replication in mammalian cells. By using mouse models to manipulate key nuclear structure genes, the research aims to clarify how spatial organization affects DNA replication processes.
Replication timing is observed in all eukaryotes analyzed so far suggesting an important and conserved function.
Despite significant advancement in the field, the molecular control of the replication-timing program is still largely unknown.
The Buonomo laboratory has recently done very innovative work in this area.
After identifying Rif1 as the only known global regulator of replication timing in mammalian cells, they have further shown that Rif1 controls chromatin architecture during replicatio…
THE UNIVERSITY OF EDINBURGH
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